2022

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes
Jeremy Vicencio*, Carlos Sánchez-Bolaños*, Ismael Moreno-Sánchez, David Brena, Dmytro Kukhtar, Miguel Ruiz-López, Mariona Cots-Ponjoan, Charles E. Vejnar, Alejandro Rubio, Natalia Rodrigo Melero, Carlo Carolis, Antonio J. Pérez-Pulido, Antonio J. Giráldez, Benjamin P. Kleinstiver, Julián Cerón*, Miguel A. Moreno-Mateos*
Nature Communications, 13, Article number: 2601 (2022) 

Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans
Carmen Martínez-Fernández, Milana Bergamino, David Brena, Natascia Ventura, Sebastian Honnen, Alberto Villanueva, Ernest Nadal, Julián Cerón*
Disease Models and Mechanisms, 2022 Mar 1;15(3):dmm049161. doi: 10.1242/dmm.049161

Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia Jungtrakoon Thamtarana P, Marucci A, Pannone L, Bonnefond A, Pezzilli S, Biagini T, Buranasupkajorn P, Hastings T, Mendonca C, Marselli L, Di Paola R, Abubakar Z, Mercuri L, Alberico F, Flex E, Ceròn J, Porta-de-la-Riva M, Ludovico O, Carella M, Martinelli S, Marchetti P, Mazza T, Froguel P, Trischitta V, Doria A, Prudente S.
J Clin Endocrinol Metab. 2022 Feb 17;107(3):668-684. doi: 10.1210/clinem/dgab790.

2021

A Living Organism in your CRISPR Toolbox: Caenorhabditis elegans Is a Rapid and Efficient Model for Developing CRISPR-Cas Technologies
Vicencio J, Cerón J*
CRISPR Journal, 2021. PMID: 33538637 DOI: 10.1089/crispr.2020.0103

Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cellstis elegans development
Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Jabalquinto-Carrasco J, Cosialls AM, Mendive-Tapia L, Kukhtar D, Martínez-Bueno MD, Lavilla R, Cerón J, Artal-Sanz M, Pons G, Iglesias-Serret D, Gil J.
Apoptosis, 2021 jan2, doi: 10.1007/s10495-020-01651-z.

2020

Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development
David Brena, Joan Bertran, Montserrat Porta-de-la-Riva, Yolanda Guillén, Eric Cornes, Dmytro Kukhtar, Lluís Campos-Vicens, Lierni Fernández, Irene Pecharroman, Albert García-López, Abul B. M. M. K. Islam, Laura Marruecos, Anna Bigas*, Julián Cerón* & Lluís Espinosa*
Scientific Reports. volume 10, Article number: 16153 (2020)

Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allow drug screens and identification of disease modifiers.
Kukhtar D*, Rubio-Peña K*, Serrat X, Cerón J.*
Human Molecular Genetics. 2020 Jan 10. pii: ddz315. doi: 10.1093

2019

CRISPR editing of sftb-1/SF3B1 in C. elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing.
Xènia Serrat, Dmytro Kukhtar, Eric Cornes, Anna Esteve-Codina, Helena Benlloch, Germano Cecere, Julián Cerón*
PLOS Genetics , 21 Oct 2019, 15(10): e1008464.

Efficient Generation of Endogenous Fluorescent Reporters by Nested CRISPR in Caenorhabditis elegans.
Vicencio J, Martínez-Fernández C, Serrat X, Cerón J*.
Genetics. 2019 Apr;211(4):1143-1154. doi: 10.1534/genetics.119.301965.

2018

Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin.
García-Rodríguez FJ, Martínez-Fernández C, Brena D, Kukhtar D, Serrat X, Nadal E, Boxem M, Honnen S, Miranda-Vizuete A, Villanueva A, Cerón J*.
Disease Models and Mechanisms 2018 Jun 21;11(6). pii: dmm033506.

Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent.
Piulats JM, Vidal A, García-Rodríguez FJ, Muñoz C, Nadal M, Moutinho C, Martínez-Iniesta M, Mora J, Figueras A, Guinó E, Padullés L, Aytés À, Molleví DG, Puertas S, Martínez-Fernández C, Castillo W, Juliachs M, Moreno V, Muñoz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germà JR, Capella G, Farré L, Morales A, Viñals F, García-Del-Muro X, Cerón J*, Villanueva A*.
Clincal Cancer Research. 2018 Aug 1;24(15):3755-3766.

2017

Effect of the diet type and temperature on the C. elegans transcriptome.
Gómez-Orte E, Cornes E, Zheleva A, Sáenz-Narciso B, de Toro M, Iñiguez M, López R, San-Juan JF, Ezcurra B, Sacristán B, Sánchez-Blanco A, Cerón J, Cabello J.
Oncotarget. 2017 Dec 21;9(11):9556-9571.

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
Xu T, Park SS, Giaimo BD, Hall D, Ferrante F, Ho DM, Hori K, Anhezini L, Ertl I, Bartkuhn M, Zhang H, Milon E, Ha K, Conlon KP, Kuick R, Govindarajoo B, Zhang Y, Sun Y, Dou Y, Basrur V, Elenitoba-Johnson KS, Nesvizhskii AI, Ceron J, Lee CY, Borggrefe T, Kovall RA, Rual JF.
EMBO Journal. 2017 Nov 2;36(21):3232-3249.

Impaired Dopamine-Dependent Locomotory Behavior of C. elegans Neuroligin Mutants Depends on the Catechol-O-Methyltransferase COMT-4.
Rodríguez-Ramos Á, Gámez-Del-Estal MM, Porta-de-la-Riva M, Cerón J, Ruiz-Rubio M.
Behavior Genetics. 2017 Nov;47(6):596-608.

2016

Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development.
Ertl I, Porta-de-la-Riva M, Gómez-Orte E, Rubio-Peña K, Aristizábal-Corrales D, Cornes E, Fontrodona L, Osteikoetxea X, Ayuso C, Askjaer P, Cabello J, Cerón J*.
Genetics. 2016 Mar;202(3):961-75.

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
Osorio FG, Soria-Valles C, Santiago-Fernández O, Bernal T, Mittelbrunn M, Colado E, Rodríguez F, Bonzon-Kulichenko E, Vázquez J, Porta-de-la-Riva M, Cerón J, Fueyo A, Li J, Green AR, Freije JM, López-Otín C.
Nature Medicine 2016 Jan;22(1):91-6.

Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression.
Shaikh MN, Gutierrez-Aviño F, Colonques J, Ceron J, Hämmerle B, Tejedor FJ.
Development. 2016 Sep 1;143(17):3195-205

2015

Modeling of autosomal-dominant retinitis pigmentosa in Caenorhabditis elegans uncovers a nexus between global impaired functioning of certain splicing factors and cell type-specific apoptosis.
Rubio-Peña K, Fontrodona L, Aristizábal-Corrales D, Torres S, Cornes E, García-Rodríguez FJ, Serrat X, González-Knowles D, Foissac S, Porta-De-La-Riva M, Cerón J*.
RNA. 2015 Dec;21(12):2119-31.

Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans
Cornes E, Porta-De-La-Riva M, Aristizábal-Corrales D, Brokate-Llanos AM, García-Rodríguez FJ, Ertl I, Díaz M, Fontrodona L, Reis K, Johnsen R, Baillie D, Muñoz MJ, Sarov M, Dupuy D, Cerón J*.
RNA. 2015 Sep;21(9):1544-53.

2014

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J.
Cell Reports. 2014 Sep 25;8(6):1609-1616.

2013

PAR-5 is a PARty hub in the germline: Multitask proteins in development and disease.
Aristizábal-Corrales D, Schwartz S Jr, Cerón J.
Worm. 2013 Jan 1;2(1):e21834.

RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery.
Fontrodona L, Porta-de-la-Riva M, Morán T, Niu W, Díaz M, Aristizábal-Corrales D, Villanueva A, Schwartz S Jr, Reinke V, Cerón J*.
PLoS Genetics. 2013 Jun;9(6):e1003543.

2012

Basic Caenorhabditis elegans methods: synchronization and observation.
Porta-de-la-Riva M, Fontrodona L, Villanueva A, Cerón J*.
Journal of Visualized Experiments. 2012 Jun 10;(64):e4019.

The 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans
Aristizábal-Corrales D, Fontrodona L, Porta-de-la-Riva M, Guerra-Moreno A, Cerón J*, Schwartz S Jr*.
Journal of Cell Science. 2012 Apr 1;125(Pt 7):1716-26.

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