Modeling Human Diseases in C. elegans group

Research lines

RNA AND DISEASE

Mechanisms of RNA processing are highly conserved from yeast to humans and are frequently altered in human diseases. We use the powerful C. elegans genetics to study RNA-related processes that are impaired in diverse diseases as cancer or retinitis pigmentosa.

CHEMORESISTANCE TO CISPLATIN

Tumors can become resistant to chemotherapeutical agents, limiting the effectiveness of the treatment. We take advantage of the toxicity of cisplatin on C. elegans to study the molecular and celular mechanisms that confer both resistance and sensitivity to chemotherapy.

CRISPR GENOME EDITING

Its short life cycle, its hermaphroditism, and its syncitial germline are advantages to use C. elegans as model to develpop CRISPR-based techniques. We work on most efficient and versatile methodologies to edit genetic locus.


Recent Publications

Mimicking of splicing-related retinitis pigmentosa mutations in C. elegans allow drug screens and identification of disease modifiers.
Kukhtar D*, Rubio-Peña K*, Serrat X, Cerón J.*
Human Molecular Genetics. 2020 Jan 10. pii: ddz315.

CRISPR editing of sftb-1/SF3B1 in C. elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing.
Xènia Serrat, Dmytro Kukhtar, Eric Cornes, Anna Esteve-Codina, Helena Benlloch, Germano Cecere, Julián Cerón*
PLoS Genetics, October 2019 ; https://doi.org/10.1371/journal.pgen.1008464

Efficient Generation of Endogenous Fluorescent Reporters by Nested CRISPR in Caenorhabditis elegans.
Vicencio J, Martínez-Fernández C, Serrat X, Cerón J.*
Genetics. 2019 Apr;211(4):1143-1154.

Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin.
García-Rodríguez FJ, Martínez-Fernández C, Brena D, Kukhtar D, Serrat X, Nadal E, Boxem M, Honnen S, Miranda-Vizuete A, Villanueva A, Cerón J.*
Disease Models and Mechanisms, 2018 Jun 21;11(6).


People


From left to right: Dmytro, David, Carmen, Jeremy, Xènia and Julián

Find us

Bellvitge Institute for Biomedical Research (IDIBELL).
Hospital Duran i Reynals.
Laboratorio de Genética Molecular, planta 3.
Gran via s/n, Km 2.7, l’Hospitalet 08907, Barcelona, Spain.

 

Contact

phone:  +34 93 260 7287
email: jceron@idibell.cat, jceronmadrigal@gmail.com
www.idibell.cat
www.gusaneros.com
www.ceronlab.com